Frozen-thawed embryo transfers: time to adopt a more "natural" approach?

J Assist Reprod Genet. 2021 Aug;38(8):1909-1911. doi: 10.1007/s10815-021-02151-y. Epub 2021 Mar 19.

Abstract

The increasing use of frozen-thawed embryo transfer (FET) cycles has magnified the focus on endometrial preparation protocols in assisted reproduction. Emerging evidence suggests that natural cycle (NC) FETs are associated with improved outcomes, and that providers should consider increasing the utilization of NC FET at the expense of the currently favored artificial cycle (AC) FET as primary method for endometrial preparation.

Keywords: Assisted reproductive technology (ART); Frozen-thawed embryo transfer (FET); In-vitro fertilization (IVF); Natural frozen-thawed embryo transfer.

MeSH terms

  • Adult
  • Cryopreservation / standards*
  • Embryo Transfer / methods*
  • Endometrium / growth & development*
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Rate
  • Reproductive Techniques, Assisted / trends*