Principles of albumin and IgG analyses in neurological disorders. III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis

Scand J Clin Lab Invest. 1977 Sep;37(5):397-401. doi: 10.1080/00365517709091498.


Fifty-nine multiple sclerosis patients were investigated with regard to blood-brain barrier function by determining the CSF-protein and the CSF/S albumin ratio. Abnormal values were found in 19% and 32% respectively. The occurrence of CSF-IgG elevation due to synthesis within the CNS was analysed by determining the CSF IgG/protein and CSF IgG/albumin ratios and the IgG-index = (CSF/S IgG ratio)/(CSF/S albumin ratio). Increased values were found in 75%, 80% and 86%, respectively. Oligoclonal IgG was found in CSF by agarose gel electrophoresis in 88% of the patients. The IgG-index is the parameter recommended for the demonstration of an IgG elevation in CSF due to synthesis within the CNS.

Publication types

  • Clinical Trial
  • Comparative Study

MeSH terms

  • Adult
  • Albumins / cerebrospinal fluid
  • Blood-Brain Barrier*
  • Central Nervous System / metabolism*
  • Cerebrospinal Fluid Proteins / analysis
  • Clinical Trials as Topic
  • Humans
  • Immunoglobulin G / biosynthesis*
  • Middle Aged
  • Multiple Sclerosis / blood
  • Multiple Sclerosis / cerebrospinal fluid
  • Multiple Sclerosis / metabolism*
  • Serum Albumin / analysis


  • Albumins
  • Cerebrospinal Fluid Proteins
  • Immunoglobulin G
  • Serum Albumin