Magnetic Particle Imaging (MPI) has shown great promise to surpass existing in vivo imaging modalities in some clinical applications. However, one of the challenges to MPI being translated into clinical practice has been the ability to scale up the selection field coils to surround a human body while being able to generate and drive a sufficiently strong magnetic field gradient. These requirements impose safety concerns as well as prohibitively high-power consumption in devices with large cylindrical volume. Therefore, we consider an alternative approach such as a single-sided topology, in which all the hardware is located on one side of the imaging volume accommodating larger subjects. Moreover, different from the previously implemented field-free point single-sided scanners, we realized a field-free line geometry providing, in principle, factor of ten higher signal and benefiting from a more robust back-projection image reconstruction technique. In this work, we present and characterize a first prototype of a single-sided MPI device with field-free-line geometry suited for in-vivo imaging of small animals as well as regions of interest in humans.
Keywords: Magnetic particle imaging (MPI); field-free line (FFL); in-vivo imaging; magnetic nanoparticles; single-sided device.