Management of Staphylococcus aureus Bloodstream Infections

Aurelia Kimmig; Stefan Hagel; Sebastian Weis; Christina Bahrs; Bettina Löffler; Mathias W Pletz

doi:10.3389/fmed.2020.616524

Management of Staphylococcus aureus Bloodstream Infections

Front Med (Lausanne). 2021 Mar 5:7:616524. doi: 10.3389/fmed.2020.616524. eCollection 2020.

Authors

Aurelia Kimmig¹, Stefan Hagel¹, Sebastian Weis^{1

2

3}, Christina Bahrs^{1

4}, Bettina Löffler⁵, Mathias W Pletz¹

Affiliations

¹ Institute for Infectious Diseases and Infection Control, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.
² Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.
³ Center for Sepsis Control and Care, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.
⁴ Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
⁵ Institute of Medical Microbiology, Jena University Hospital, Friedrich-Schiller-University Jena, Jena, Germany.

Abstract

Staphylococcus aureus bloodstream infections are associated with a high morbidity and mortality. Nevertheless, significance of a positive blood culture with this pathogen is often underestimated or findings are misinterpreted as contamination, which can result in inadequate diagnostic and therapeutic consequences. We here review and discuss current diagnostic and therapeutic key elements and open questions for the management of Staphylococcus aureus bloodstream infections.

Keywords: Staphylococcus aureus blood stream infections; current recommendations; diagnostic and therapeutic algorithm; endocarditis; open questions.

Publication types

Review