Methicillin-Resistant Staphylococcus Aureus (MRSA) Pyruvate Kinase (PK) Inhibitors and their Antimicrobial Activities

Abstract

Resistance to antibiotics has existed in the health care and community settings. Thus, developing novel antibiotics is urgent. Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase (PK) is crucial for the survival of bacteria, making it a novel antimicrobial target. In the past decade, the most commonly reported PK inhibitors include indole, flavonoid, phenazine derivatives from natural products' small molecules or their analogs, or virtual screening from small molecule compound library. This review covers the PK inhibitors and their antimicrobial activities reported from the beginning of 2011 through mid-2020. The Structure-Activity Relationships (SARs) were discussed briefly as well.

Keywords: Methicillin-resistant Staphylococcus aureus; flavonoids; hydrazones; indoles; nitro compounds; phenazines; pyruvate kinase antimicrobial.