Rare variants increase the risk of severe COVID-19

Elife. 2021 Mar 23;10:e67860. doi: 10.7554/eLife.67860.

Authors

Frank L van de Veerdonk¹, Mihai G Netea^{1

2}

Affiliations

¹ Department of Internal Medicine, Radboudumc Center for Infectious Diseases, Nijmegen, Netherlands.
² Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, Germany.

Abstract

Evidence is mounting that rare loss-of-function variants in the TLR7 gene predispose men with no medical history to severe forms of COVID-19.

Keywords: COVID-19; LASSO logistic regression analysis; TLR7; genetics; genomics; human; medicine.

© 2021, van de Veerdonk and Netea.

Publication types

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MeSH terms

COVID-19*
Case-Control Studies
Humans
Male
SARS-CoV-2
Toll-Like Receptor 7*

Substances

Toll-Like Receptor 7