Rare variants increase the risk of severe COVID-19

Elife. 2021 Mar 23;10:e67860. doi: 10.7554/eLife.67860.


Evidence is mounting that rare loss-of-function variants in the TLR7 gene predispose men with no medical history to severe forms of COVID-19.

Keywords: COVID-19; LASSO logistic regression analysis; TLR7; genetics; genomics; human; medicine.

Publication types

  • Comment

MeSH terms

  • COVID-19*
  • Case-Control Studies
  • Humans
  • Male
  • SARS-CoV-2
  • Toll-Like Receptor 7*


  • Toll-Like Receptor 7