Gaining Insight into Vitiligo Genetics through the Lens of a Large Epidemiologic Study

Ken Okamura; Manuel Garber; John E Harris

doi:10.1016/j.jid.2020.10.005

Gaining Insight into Vitiligo Genetics through the Lens of a Large Epidemiologic Study

J Invest Dermatol. 2021 Apr;141(4):718-721. doi: 10.1016/j.jid.2020.10.005.

Authors

Ken Okamura¹, Manuel Garber², John E Harris³

Affiliations

¹ Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
² Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
³ Department of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. Electronic address: john.harris@umassmed.edu.

PMID: 33752810
DOI: 10.1016/j.jid.2020.10.005

Abstract

Several epidemiologic studies and GWASs have implicated genetic factors in the pathogenesis of vitiligo. The report by Kim et al. (2020) describes a prospective cohort study from Korea that has the greatest statistical power to date in addressing the epidemiology of vitiligo inheritance. The authors reported the incidence risk ratios in individuals whose first-degree relatives or spouses are affected, providing clear evidence that both genetic and nongenetic factors influence the pathogenesis of vitiligo.

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MeSH terms

Epidemiologic Studies
Genome-Wide Association Study
Humans
Prospective Studies
Republic of Korea
Vitiligo* / epidemiology
Vitiligo* / genetics