On the novel mechanisms for social memory and the emerging role of neurogenesis

Abstract

Social memory (SM) is a key element in social cognition and it encompasses the neural representation of conspecifics, an essential information to guide behavior in a social context. Here we evaluate classical and cutting-edge studies on neurobiology of SM, using as a guiding principle behavioral tasks performed in adult rodents. Our review highlights the relevance of the hippocampus, especially the CA2 region, as a neural substrate for SM and suggest that neural ensembles in the olfactory bulb may also encode SM traces. Compared to other hippocampus-dependent memories, much remains to be done to describe the neurobiological foundations of SM. Nonetheless, we argue that special attention should be paid to neurogenesis. Finally, we pinpoint the remaining open question on whether the hippocampal adult neurogenesis acts through pattern separation to permit the discrimination of highly similar stimuli during behavior.

Keywords: Hippocampus; Neurogenesis; Olfactory bulb; Social isolation; Social memory.