Extracellular vesicles in immunomodulation and tumor progression

Nat Immunol. 2021 May;22(5):560-570. doi: 10.1038/s41590-021-00899-0. Epub 2021 Mar 22.


Extracellular vesicles have emerged as prominent regulators of the immune response during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a critical role in immunomodulation. Here, we identify the role of EVs as mediators of communication between cancer and immune cells. This expanded role of EVs may shed light on the mechanisms behind tumor progression and provide translational diagnostic and prognostic tools for immunologists.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Disease Progression
  • Extracellular Vesicles / immunology*
  • Extracellular Vesicles / metabolism
  • Extracellular Vesicles / pathology
  • Humans
  • Immunotherapy
  • Neoplasms / immunology*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neoplasms / therapy
  • Signal Transduction
  • Tumor Escape*
  • Tumor Microenvironment