Building patient-specific models for receptor tyrosine kinase signaling networks

FEBS J. 2022 Jan;289(1):90-101. doi: 10.1111/febs.15831. Epub 2021 May 14.


Cancer progresses due to changes in the dynamic interactions of multidimensional factors associated with gene mutations. Cancer research has actively adopted computational methods, including data-driven and mathematical model-driven approaches, to identify causative factors and regulatory rules that can explain the complexity and diversity of cancers. A data-driven, statistics-based approach revealed correlations between gene alterations and clinical outcomes in many types of cancers. A model-driven mathematical approach has elucidated the dynamic features of cancer networks and identified the mechanisms of drug efficacy and resistance. More recently, machine learning methods have emerged that can be used for mining omics data and classifying patient. However, as the strengths and weaknesses of each method becoming apparent, new analytical tools are emerging to combine and improve the methodologies and maximize their predictive power for classifying cancer subtypes and prognosis. Here, we introduce recent advances in cancer systems biology aimed at personalized medicine, with focus on the receptor tyrosine kinase signaling network.

Keywords: RTK signaling; cancer; machine learning; mathematical modeling; omics; patient-specific model.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computational Biology
  • Drug Resistance, Neoplasm / genetics*
  • Gene Regulatory Networks
  • Humans
  • Machine Learning
  • Models, Theoretical*
  • Neoplasms / drug therapy
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Precision Medicine
  • Receptor Protein-Tyrosine Kinases / genetics*
  • Signal Transduction / genetics
  • Systems Biology / trends


  • Receptor Protein-Tyrosine Kinases