Abstract
Fortuneicyclidins A (1) and B (2), a pair of epimeric pyrrolizidine alkaloids containing an unprecedented 7-azatetracyclo[5.4.3.0.02,8]tridecane core, were isolated from the seeds of Cephalotaxus fortunei, along with two biogenetically relative known analogues, 3 and 4. The structures were determined by multiple spectral techniques and chemical derivatization methods. Compound 1 showed inhibitory activity against α-glucosidase.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkanes / chemistry
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Antineoplastic Agents, Phytogenic / pharmacology*
-
Cephalotaxus / chemistry*
-
Glycoside Hydrolase Inhibitors / chemistry
-
Glycoside Hydrolase Inhibitors / isolation & purification
-
Glycoside Hydrolase Inhibitors / pharmacology*
-
Molecular Structure
-
Plant Leaves / chemistry*
-
Pyrrolizidine Alkaloids / chemistry
-
Pyrrolizidine Alkaloids / isolation & purification
-
Pyrrolizidine Alkaloids / pharmacology*
Substances
-
Alkanes
-
Antineoplastic Agents, Phytogenic
-
Glycoside Hydrolase Inhibitors
-
Pyrrolizidine Alkaloids
-
tridecane