Fortuneicyclidins A and B, Pyrrolizidine Alkaloids with a 7-Azatetracyclo[5.4.3.0.02,8]tridecane Core, from Cephalotaxus fortunei

Org Lett. 2021 Apr 2;23(7):2807-2810. doi: 10.1021/acs.orglett.1c00738. Epub 2021 Mar 23.

Abstract

Fortuneicyclidins A (1) and B (2), a pair of epimeric pyrrolizidine alkaloids containing an unprecedented 7-azatetracyclo[5.4.3.0.02,8]tridecane core, were isolated from the seeds of Cephalotaxus fortunei, along with two biogenetically relative known analogues, 3 and 4. The structures were determined by multiple spectral techniques and chemical derivatization methods. Compound 1 showed inhibitory activity against α-glucosidase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / chemistry
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cephalotaxus / chemistry*
  • Glycoside Hydrolase Inhibitors / chemistry
  • Glycoside Hydrolase Inhibitors / isolation & purification
  • Glycoside Hydrolase Inhibitors / pharmacology*
  • Molecular Structure
  • Plant Leaves / chemistry*
  • Pyrrolizidine Alkaloids / chemistry
  • Pyrrolizidine Alkaloids / isolation & purification
  • Pyrrolizidine Alkaloids / pharmacology*

Substances

  • Alkanes
  • Antineoplastic Agents, Phytogenic
  • Glycoside Hydrolase Inhibitors
  • Pyrrolizidine Alkaloids
  • tridecane