Engaging the front wheels to drive through fibrous terrain

Dev Cell. 2021 Mar 22;56(6):723-725. doi: 10.1016/j.devcel.2021.03.002.


In this issue of Developmental Cell, Doyle and colleagues identify periodic anterior contraction as a characteristic feature of fibroblasts and mesenchymal cancer cells embedded in 3D collagen gels. This contractile mechanism generates a matrix prestrain required for crawling in fibrous 3D environments.

Publication types

  • Comment

MeSH terms

  • Collagen*
  • Fibroblasts*
  • Gels
  • Humans


  • Gels
  • Collagen