Sinonasal cancers treatments: state of the art

Curr Opin Oncol. 2021 May 1;33(3):196-205. doi: 10.1097/CCO.0000000000000726.


Purpose of review: The present review provides the reader with the state-of-the-art concepts of sinonasal oncology in view of the latest literature data.

Recent findings: Most recent publications in sinonasal oncology assessed treatment timing, centralization, surgical approach, margin status, orbit/neck management, salvage strategies, emerging surgical technologies, intensity-modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT), particle radiotherapy, and neoadjuvant chemotherapy.

Summary: Indications to endoscopic surgery for sinonasal cancer have plateaued and are unlikely to further expand. Endoscopic surgery provides noninferior results compared to open surgery and best suits timing constraints imposed by multimodal treatment. Management of orbit-encroaching sinonasal cancer is remarkably improving mostly owing to optimal use of nonsurgical strategies. Prognostic value of the margin status and management of the nodal basin and recurrent sinonasal tumors are far from being fully elucidated. Most promising surgical technologies are surgical navigation, optical imaging, and radiofrequency-aided ablation. IMRT and VMAT have theoretical technical advantages that are in the process of being clinically demonstrated. Pieces of evidence are progressively confirming the physical and radiobiological advantages offered by particle radiotherapy. Systemic therapy is being tested mostly in the neoadjuvant setting with the aim of improving outcomes in locally advanced sinonasal cancers; response to induction chemotherapy could better select a further locoregional approach.

Trial registration: NCT02998385.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Endoscopy
  • Humans
  • Neoadjuvant Therapy
  • Paranasal Sinus Neoplasms / drug therapy
  • Paranasal Sinus Neoplasms / radiotherapy
  • Paranasal Sinus Neoplasms / surgery
  • Paranasal Sinus Neoplasms / therapy*
  • Radiofrequency Ablation
  • Radiotherapy, Intensity-Modulated
  • Randomized Controlled Trials as Topic
  • Salvage Therapy
  • Squamous Cell Carcinoma of Head and Neck / drug therapy
  • Squamous Cell Carcinoma of Head and Neck / radiotherapy
  • Squamous Cell Carcinoma of Head and Neck / surgery
  • Squamous Cell Carcinoma of Head and Neck / therapy*

Associated data