Repeated surgery for hemorrhagic brain metastases from hepatocellular carcinoma: palliation or effective part of a multimodal treatment? A case-based approach

Br J Neurosurg. 2023 Dec;37(6):1770-1773. doi: 10.1080/02688697.2021.1903394. Epub 2021 Mar 24.

Abstract

Brain metastases from hepatocellular carcinoma (HCCBM) are encountered very rarely in clinical practice, especially in western countries. Only a minority of patients undergoes resective surgery, as clinical picture is usually complex and presentation is often catastrophic with intra-cerebral hemorrhage (ICH). Neurosurgical intervention can be not only life-saving but may also alleviate significantly the burden of symptoms. We present the case of a patient with six metachronous hemorrhagic HCCBM in which emergent surgery extended survival by 9 months, of which seven spent in near-normal life quality, stressing the role of neurosurgery in the evaluation of HCCBM patients.

Keywords: Hepatocellular carcinoma; brain metastasis; hemorrhage; neurosurgery; patient selection; survival.

Publication types

  • Case Reports

MeSH terms

  • Brain Neoplasms* / secondary
  • Brain Neoplasms* / surgery
  • Carcinoma, Hepatocellular* / secondary
  • Carcinoma, Hepatocellular* / surgery
  • Cerebral Hemorrhage / etiology
  • Cerebral Hemorrhage / surgery
  • Combined Modality Therapy
  • Humans
  • Liver Neoplasms* / pathology
  • Liver Neoplasms* / surgery