Hybrid hyperalignment: A single high-dimensional model of shared information embedded in cortical patterns of response and functional connectivity

Neuroimage. 2021 Jun;233:117975. doi: 10.1016/j.neuroimage.2021.117975. Epub 2021 Mar 21.

Abstract

Shared information content is represented across brains in idiosyncratic functional topographies. Hyperalignment addresses these idiosyncrasies by using neural responses to project individuals' brain data into a common model space while maintaining the geometric relationships between distinct patterns of activity or connectivity. The dimensions of this common model capture functional profiles that are shared across individuals such as cortical response profiles collected during a common time-locked stimulus presentation (e.g. movie viewing) or functional connectivity profiles. Hyperalignment can use either response-based or connectivity-based input data to derive transformations that project individuals' neural data from anatomical space into the common model space. Previously, only response or connectivity profiles were used in the derivation of these transformations. In this study, we developed a new hyperalignment algorithm, hybrid hyperalignment, that derives transformations based on both response-based and connectivity-based information. We used three different movie-viewing fMRI datasets to test the performance of our new algorithm. Hybrid hyperalignment derives a single common model space that aligns response-based information as well as or better than response hyperalignment while simultaneously aligning connectivity-based information better than connectivity hyperalignment. These results suggest that a single common information space can encode both shared cortical response and functional connectivity profiles across individuals.

Keywords: Functional alignment; Functional connectivity; Hyperalignment; Naturalistic stimuli; fMRI.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Brain Mapping / methods*
  • Cerebral Cortex / diagnostic imaging*
  • Cerebral Cortex / physiology
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Motion Pictures*
  • Nerve Net / diagnostic imaging*
  • Nerve Net / physiology
  • Photic Stimulation / methods