Hypercalcaemia: An Extremely Rare Presentation of Hepatosplenic T-Cell Lymphoma

Sara Almeida Ramalho; Francisca Abecasis; Letícia Santos; Vanessa Leite; Diogo Gonçalves; Inês Pintassilgo; Ana Luisa Broa

doi:10.12890/2021_002360

Hypercalcaemia: An Extremely Rare Presentation of Hepatosplenic T-Cell Lymphoma

Eur J Case Rep Intern Med. 2021 Feb 25;8(3):002360. doi: 10.12890/2021_002360. eCollection 2021.

Authors

Sara Almeida Ramalho¹, Francisca Abecasis¹, Letícia Santos¹, Vanessa Leite¹, Diogo Gonçalves², Inês Pintassilgo¹, Ana Luisa Broa¹

Affiliations

¹ Internal Medicine Department, Hospital Garcia de Orta, Almada, Portugal.
² Pathology Department, Hospital Garcia de Orta, Almada, Portugal.

Abstract

Hypercalcaemia is a frequent finding in malignancies including lymphomas. However, there are no reports of hypercalcaemia in hepatosplenic T-cell lymphoma (HSTCL). HSTCL is a rare and aggressive neoplasm which is usually difficult to diagnose. We present a case of HSTCL in which hypercalcaemia was the initial presentation.

Learning points: Hepatosplenic T-cell lymphoma (HSTCL) is difficult to diagnose, has a poor prognosis and usually presents with hepatosplenomegaly, B symptoms and cytopenias.Hypercalcaemia is an extremely rare clinical presentation of HSTCL.Severe hypercalcaemia is a life-threatening condition and should always be corrected and investigated.

Keywords: B symptoms; Hypercalcaemia; bone marrow; hepatosplenic lymphoma; hepatosplenomegaly.