Early recognition of PIMS-TS: a single centre retrospective review

BMJ Paediatr Open. 2021 Mar 8;5(1):e001011. doi: 10.1136/bmjpo-2020-001011. eCollection 2021.

Abstract

Introduction: Research into paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) has focused on tertiary level management. This review reports on symptoms and investigations at presentation.

Methods: Single centre retrospective case note analysis of patients fulfilling PIMS-TS diagnostic criteria from March to May 2020 in a London district level university hospital.

Results: Six patients presented in the week prior to their final diagnosis with fever and non-specific symptoms. Raised C-reactive protein (CRP), lymphopenia and hyponatraemia were noted. Kawasaki-like symptoms were under-represented in all patients.

Interpretation: The results suggest that a proportion of children with early PIMS-TS present with a non-specific febrile illness and abnormal blood results. Further research is needed to determine the most appropriate identification and follow-up of these children.

Keywords: COVID-19; virology.

Publication types

  • Review

MeSH terms

  • COVID-19* / complications
  • Child
  • Humans
  • Retrospective Studies
  • SARS-CoV-2
  • Systemic Inflammatory Response Syndrome

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related