Abstract
Despite high levels of CXCR3 ligands in mechanically ventilated COVID-19 patients, BALF CD8 T cells were not enriched in CXCR3+ cells but rather CCR6+ , likely due to high CCL20 levels in BALF, and had very high PD-1 expression. In mechanically ventilated, but not ward, patients Th-1 immunity is impaired. .
Keywords:
CCL20; CCR6; COVID-19; T cells.
© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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CD8-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / pathology
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COVID-19 / immunology*
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COVID-19 / pathology
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COVID-19 / therapy
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Chemokine CCL20 / immunology*
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Female
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Humans
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Lung / immunology*
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Lung / pathology
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Lymphocyte Count
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Male
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Middle Aged
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Receptors, CCR6 / immunology*
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Respiration, Artificial*
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SARS-CoV-2 / immunology*
Substances
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CCL20 protein, human
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CCR6 protein, human
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Chemokine CCL20
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Receptors, CCR6