Imatinib-induced eruptive nevi

Clin Exp Pharmacol Physiol. 2021 Sep;48(9):1298-1299. doi: 10.1111/1440-1681.13491. Epub 2021 Mar 25.

Abstract

Imatinib mesylate is a tyrosine kinase inhibitor used in the treatment of a variety of oncological conditions. It has been associated with a spectrum of pigmentary cutaneous side effects. Despite the well-known association of eruptive melanocytic nevi with the use of other tyrosine kinase inhibitors, this phenomenon has not been linked to the administration of imatinib. We present the first case of imatinib-induced eruptive nevi in an 18-year-old patient with acute lymphocytic leukaemia in remission.

Keywords: eruptive nevi; melanocytic nevi; tyrosine kinase inhibitors.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adolescent
  • Antineoplastic Agents* / adverse effects
  • Antineoplastic Agents* / therapeutic use
  • Humans
  • Imatinib Mesylate* / adverse effects
  • Imatinib Mesylate* / therapeutic use
  • Male
  • Nevus, Pigmented* / chemically induced
  • Nevus, Pigmented* / pathology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
  • Protein Kinase Inhibitors / adverse effects

Substances

  • Antineoplastic Agents
  • Imatinib Mesylate
  • Protein Kinase Inhibitors