Drugging multiple same-allele driver mutations in cancer

Expert Opin Drug Discov. 2021 Aug;16(8):823-828. doi: 10.1080/17460441.2021.1905628. Epub 2021 Mar 26.

Authors

Ruth Nussinov^{1

2}, Mingzhen Zhang¹, Ryan Maloney³, Hyunbum Jang¹

Affiliations

¹ Computational Structural Biology Section, Frederick National Laboratory for Cancer Research in the Laboratory of Cancer ImmunoMetabolism, National Cancer Institute, Frederick U.S.A.
² Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University Israel.
³ Computational Structural Biology Section, Laboratory of Cancer ImmunoMetabolism, National Cancer Institute, Frederick USA.

No abstract available

Keywords: Drug resistance; activating mutations; cancer; double mutations; drug discovery; k-ras; pi3k; signaling.

Publication types

Editorial
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

MeSH terms

Alleles
Humans
Mutation
Neoplasms* / drug therapy
Neoplasms* / genetics

Grants and funding

Z01 BC010440/ImNIH/Intramural NIH HHS/United States