The e-psychonaut drugs' psychopharmacology

Curr Opin Pharmacol. 2021 Apr:57:165-174. doi: 10.1016/j.coph.2021.02.008. Epub 2021 Mar 25.


The focus here was on the pharmacological and clinical pharmacological issues pertaining to the vast range of drugs (e.g. synthetic cannabimimetics, synthetic opioids, novel stimulants, novel psychedelics, PCP/ketamine-like compounds, prescribed medicinal compounds and popular psychotropic herbs/plants) discussed by Internet-based enthusiasts of new/novel psychoactive substances (NPS), 'e-psychonauts'. Currently ongoing related in silico studies, followed by further in vitro and in vivo/preclinical studies, will hopefully provide important findings in terms of which molecules within each given NPS class may present with higher levels of receptor affinities, and hence clinical potency. Understanding the pharmacological characteristics/potency of those novel recreational molecules will hopefully help in predicting related NPS diffusion, morbidity and possible lethality data.

Keywords: Addiction; Drug abuse; NPS; New psychoactive substances; Novel psychoactive substances; Psychopharmacology; e-psychonauts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Analgesics, Opioid
  • Humans
  • Pharmaceutical Preparations*
  • Psychopharmacology*
  • Psychotropic Drugs / adverse effects


  • Analgesics, Opioid
  • Pharmaceutical Preparations
  • Psychotropic Drugs