Maternal Angiotensin Increases Placental Leptin in Early Gestation via an Alternative Renin-Angiotensin System Pathway: Suggesting a Link to Preeclampsia

Hypertension. 2021 May 5;77(5):1723-1736. doi: 10.1161/HYPERTENSIONAHA.120.16425. Epub 2021 Mar 29.

¹ From the Division of Cell Biology, Histology and Embryology (O.N., A.E.-H., T.K., D.F., B.H., M.G.), Medical University of Graz, Austria.
² Berlin Institute of Systems Biology, Max Delbrueck Centre for Molecular Medicine in the Helmholtz Association, Germany (C.F., S.G.).
³ Experimental Clinical Research Centre, Max Delbrueck Center for Molecular Medicine in the Helmholtz Association and Charité Berlin, Germany (S.G., R.D., F.H.).
⁴ DZHK (German Center for Cardiovascular Research), partner site Berlin, Germany (S.G.).
⁵ Berlin Institute of Health (BIH), Berlin, Germany (S.G.).
⁶ Gottfried Schatz Research Centre and Department of Obstetrics and Gynecology (G.D., M.K., C.S., C.W.), Medical University of Graz, Austria.
⁷ Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway (A.C.S., M.S.).
⁸ Division of Obstetrics and Gynecology, Oslo University Hospital, Norway (A.C.S., M.S.).
⁹ Division of Obstetrics and Gynecology, University Hospital Schleswig-Holstein, Kiel, Germany (U.P.).
¹⁰ Molecular and Clinical Sciences Research Institute, St George's, University of London, United Kingdom (J.E.C., G.S.W.).
¹¹ Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, United Kingdom (B.T.).

Abstract

[Figure: see text].

Keywords: candesartan; leptin; oxygen; respiration; trophoblasts.