Effect of Intensive Blood Pressure Control on Aortic Stiffness in the SPRINT-HEART

Bharathi Upadhya; Nicholas M Pajewski; Michael V Rocco; W Gregory Hundley; Gerard Aurigemma; Craig A Hamilton; Jeffrey T Bates; Jiang He; Jing Chen; Michel Chonchol; Steve P Glasser; Adriana M Hung; Roberto Pisoni; Henry Punzi; Mark A Supiano; Robert Toto; Addison Taylor; Dalane W Kitzman; SPRINT Research Group

doi:10.1161/HYPERTENSIONAHA.120.16676

Effect of Intensive Blood Pressure Control on Aortic Stiffness in the SPRINT-HEART

Hypertension. 2021 May 5;77(5):1571-1580. doi: 10.1161/HYPERTENSIONAHA.120.16676. Epub 2021 Mar 29.

Authors

Bharathi Upadhya¹, Nicholas M Pajewski², Michael V Rocco³, W Gregory Hundley⁴, Gerard Aurigemma⁵, Craig A Hamilton⁶, Jeffrey T Bates⁷, Jiang He⁸, Jing Chen⁸, Michel Chonchol⁹, Steve P Glasser¹⁰, Adriana M Hung¹¹, Roberto Pisoni¹², Henry Punzi¹³, Mark A Supiano¹⁴, Robert Toto¹⁵, Addison Taylor⁷, Dalane W Kitzman¹; SPRINT Research Group

Affiliations

¹ Cardiovascular Medicine Section (B.U., D.W.K.), Wake Forest School of Medicine, Winston-Salem, NC.
² Department of Biostatistics and Data Science (N.M.P.), Wake Forest School of Medicine, Winston-Salem, NC.
³ Nephrology Section, Department of Internal Medicine (M.V.R.), Wake Forest School of Medicine, Winston-Salem, NC.
⁴ Pauley Heart Center Department of Internal Medicine at Virginia Commonwealth University Health Sciences Richmond (W.G.H.).
⁵ Cardiovascular Medicine Section, University of Massachusetts Medical School, Worcester (G.A.).
⁶ Biomedical Engineering (C.A.H.), Wake Forest School of Medicine, Winston-Salem, NC.
⁷ Department of Medicine, Michael E. DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX (J.T.B., A.T.).
⁸ Division of Nephrology & Hypertension, Tulane University School of Public Health and Tropical Medicine, Department of Medicine, Tulane University, New Orleans, LA (J.H., J.C.).
⁹ Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora (M.C.).
¹⁰ UAB School of Public Health, University of Alabama, Birmingham (S.P.G.).
¹¹ Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (A.M.H.).
¹² Nephrology Section, Medical University of South Carolina, Ralph H. Johnson VA Medical Center, Charleston (R.P.).
¹³ Internal Medicine, Trinity Hypertension and Metabolic Research Institute, Punzi Medical Center, Carrollton, TX (H.P.).
¹⁴ Geriatrics Division, VA Salt Lake City Geriatric Research, Education, and Clinical Center, University of Utah School of Medicine University of Utah School of Medicine, Salt Lake City (M.A.S.).
¹⁵ Nephrology Section, University of Texas Southwestern Medical Center, Dallas (R.T.).

Abstract

[Figure: see text].

Trial registration: ClinicalTrials.gov NCT01206062.

Keywords: aging; blood pressure; elasticity; heart failure; magnetic resonance imaging.

Publication types

Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aged
Antihypertensive Agents / pharmacology*
Antihypertensive Agents / therapeutic use
Aorta / diagnostic imaging
Aorta / drug effects*
Aorta / physiopathology
Blood Pressure / drug effects*
Female
Humans
Hypertension / diagnostic imaging
Hypertension / drug therapy*
Hypertension / physiopathology
Magnetic Resonance Imaging, Cine
Male
Middle Aged
Registries
Vascular Stiffness / drug effects*

Effect of Intensive Blood Pressure Control on Aortic Stiffness in the SPRINT-HEART

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

Associated data

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