Editorial: Attention-Deficit/Hyperactivity Disorder Polygenic Scores in Context: Interpretations, Implications, and Directions for Future Research

J Am Acad Child Adolesc Psychiatry. 2021 Oct;60(10):1178-1180. doi: 10.1016/j.jaac.2021.03.007. Epub 2021 Mar 25.

Abstract

During the past 15 years, genome-wide association studies (GWASs) have been instrumental for identifying common genetic variants that influence complex traits. The latest attention-deficit/hyperactivity disorder (ADHD) GWAS, published in 2019, identified for the first time 12 loci significantly associated with ADHD.1 Since then a large number of studies have used the summary statistics of this GWAS to calculate individual polygenic scores (PGSs) in independent genotyped samples to explore how the ADHD PGS associates with relevant outcomes. The study by Ronald et al.2 synthesized the available literature on ADHD PGS and concluded that the ADHD PGS is robust and reliable, but not yet useful in clinical practice.

Publication types

  • Editorial
  • Comment

MeSH terms

  • Attention Deficit Disorder with Hyperactivity* / genetics
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Multifactorial Inheritance / genetics