A comparison of plasma homovanillic acid concentrations in schizophrenic patients and normal controls

Arch Gen Psychiatry. 1988 Jun;45(6):561-3. doi: 10.1001/archpsyc.1988.01800300057006.


Plasma homovanillic acid concentrations, a potential index of central dopamine turnover, were examined in normal control subjects and chronic schizophrenic patients over a 12-hour period, including the period of sleep. Plasma homovanillic acid concentrations were lower in schizophrenic patients compared with normal controls at all times; however, within the group of schizophrenics, the more symptomatic patients had higher plasma homovanillic acid concentrations than the less severely ill patients. These data are consistent with a more complex role of dopamine in schizophrenia than was previously conceptualized.

MeSH terms

  • Adult
  • Brain / metabolism
  • Chronic Disease
  • Circadian Rhythm
  • Dopamine / metabolism
  • Dopamine / physiology
  • Homovanillic Acid / blood*
  • Hospitalization
  • Humans
  • Male
  • Psychiatric Status Rating Scales
  • Schizophrenia / blood*
  • Schizophrenia / metabolism
  • Schizophrenia / physiopathology
  • Schizophrenic Psychology


  • Dopamine
  • Homovanillic Acid