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. 2021 Jul;37(7):1005-1009.
doi: 10.1007/s12264-021-00669-w. Epub 2021 Mar 29.

Restricted Feeding Resets Endogenous Circadian Rhythm in Female Mice Under Constant Darkness

Yue Mei  1   2   3 , Huajing Teng  1   4 , Zhigang Li  1 , Cheng Zeng  1   2 , Yuanyuan Li  1   2 , Wei Song  1   2 , Kaifan Zhang  5 , Zhong Sheng Sun  6   7   8   9 , Yan Wang  10   11
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Free PMC article

Restricted Feeding Resets Endogenous Circadian Rhythm in Female Mice Under Constant Darkness

Yue Mei et al. Neurosci Bull. 2021 Jul.
Free PMC article
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
The wheel-running activity of male and female mice with restricted feeding (RF) under constant darkness (DD). A Representative activity of male and female mice (horizontal axis, 48 h; vertical axis, 145 consecutive days; blue lines, shifting stage; red lines, synchronization stage). B Activity of mice with RF under DD [grey region, feeding time; region enclosed by red lines, food anticipatory activity (FAA); n = 7 for male and n = 8 for female mice]. C Phase-shifting rate in male and female mice with DD/RF at 0 h–12 h (left, shifting stage; right, synchronization stage; **P < 0.01, ***P < 0.001). D Activity and rate of phase-shifting of male and female mice with intact gonads (upper) or gonadectomy (lower) under DD/RF 0–12 (n = 8 per group; horizontal axis, 48 h; vertical axis, consecutive days; light grey, feeding time; light red, dark phase; red line, general phase shifting; *P < 0.05, ***P < 0.001).
Fig. 2
Fig. 2
Gonadectomy changes the wheel-running activity of mice under DD/RF at 4 h–9 h. A Representative phases of male and female mice with intact gonads (upper) or gonadectomy (lower) under DD/RF at 4 h–9 h over a period of 75 days (light grey, feeding time; light red, dark phase; n = 8 mice per group). B Phase-shifting rates of male and female mice with intact gonads or gonadectomy under DD/RF at 4 h–9 h (n = 8 mice per group; *P < 0.05, **P < 0.01). C Daily food consumption of male and female mice with intact gonads or gonadectomy under DD/RF at 4 h–9 h (n = 8 mice per group). D Average food consumption normalized to body weight of male and female mice with intact gonads or gonadectomy under DD/RF at 4 h–9 h (n = 8 mice per group, *P < 0.05). E Body weight of male and female mice with intact gonads or gonadectomy before and after DD/RF at 4 h–9 h (n = 8 mice per group). F Androgen receptor (AR) levels in the ventromedial core region of the SCN in male and female mice with intact gonads or gonadectomy under DD/RF at 4 h–9 h (n = 8 sections in 4 mice per group; ***P < 0.001; scale bar, 25 μm).
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