Discrepancies of polygenic effects on symptom dimensions between adolescents and adults with ADHD

Psychiatry Res Neuroimaging. 2021 May 30:311:111282. doi: 10.1016/j.pscychresns.2021.111282. Epub 2021 Mar 20.


A significant proportion of individuals with attention-deficit/hyperactivity disorder (ADHD) show persistence into adulthood. The genetic and neural correlates of ADHD in adolescents versus adults remain poorly characterized. We investigated ADHD polygenic risk score (PRS) in relation to previously identified gray matter (GM) patterns, neurocognitive, and symptom findings in the same ADHD sample (462 adolescents & 422 adults from the NeuroIMAGE and IMpACT cohorts). Significant effects of ADHD PRS were found on hyperactivity and impulsivity symptoms in adolescents, hyperactivity symptom in adults, but not GM volume components. A distinct PRS effect between adolescents and adults on individual ADHD symptoms is suggested.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Attention
  • Attention Deficit Disorder with Hyperactivity* / genetics
  • Gray Matter
  • Humans
  • Impulsive Behavior
  • Multifactorial Inheritance / genetics