Diffusion and uptake of dopamine in rat caudate and nucleus accumbens compared using fast cyclic voltammetry

Brain Res. 1988 May 17;448(2):381-5. doi: 10.1016/0006-8993(88)91282-6.


Fast cyclic voltammetry was used in the caudate and nucleus accumbens of anaesthetised rats to study the release and reuptake of dopamine following stimulation of the median forebrain bundle. Dopamine uptake was significantly slower in accumbens than caudate, indicating a lower number of functional uptake sites. This implies that dopamine may be able to diffuse further from its sites of release in nucleus accumbens than in caudate and thus may have a neuromodulator role in this region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caudate Nucleus / metabolism*
  • Caudate Nucleus / physiology
  • Dopamine / metabolism*
  • Electric Stimulation
  • Electrochemistry*
  • Male
  • Nucleus Accumbens / metabolism*
  • Nucleus Accumbens / physiology
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine / metabolism*
  • Receptors, Dopamine / physiology
  • Septal Nuclei / metabolism*
  • Time Factors


  • Receptors, Dopamine
  • Dopamine