Dihydropyriculol produced by Pyricularia oryzae inhibits the growth of Streptomyces griseus

Biosci Biotechnol Biochem. 2021 Apr 24;85(5):1290-1293. doi: 10.1093/bbb/zbab021.

Abstract

Dihydropyriculol is a major secondary metabolite of Pyricularia oryzae. However, the biological activity of dihydropyriculol has not been reported. Here, we showed that dihydropyriculol has inhibitory activity against Streptomyces griseus. Localization analysis of dihydropyriculol revealed that dihydropyriculol could reach to S. griseus under confrontation culture. These results suggest that dihydropyriculol can be used as a chemical weapon against S. griseus.

Keywords: Pyricularia oryzae; chemical interaction; dihydropyriculol; natural products.

MeSH terms

  • Anti-Bacterial Agents / biosynthesis
  • Anti-Bacterial Agents / toxicity*
  • Antibiosis
  • Ascomycota / drug effects
  • Ascomycota / metabolism*
  • Ascomycota / pathogenicity
  • Benzaldehydes / metabolism
  • Benzaldehydes / toxicity*
  • Cycloheximide / pharmacology
  • Fatty Alcohols / metabolism
  • Fatty Alcohols / toxicity*
  • Gentamicins / pharmacology
  • Hygromycin B / pharmacology
  • Microbial Sensitivity Tests
  • Secondary Metabolism / drug effects
  • Streptomyces griseus / drug effects*
  • Streptomyces griseus / growth & development
  • Toxins, Biological / biosynthesis
  • Toxins, Biological / toxicity*

Substances

  • Anti-Bacterial Agents
  • Benzaldehydes
  • Fatty Alcohols
  • Gentamicins
  • Toxins, Biological
  • Hygromycin B
  • Cycloheximide
  • antibiotic G 418

Supplementary concepts

  • Pyricularia oryzae