[Quantitative morphological investigation of the effect of thiobutabarbitone sodium anaesthesia on the endocrine and exocrine pancreas of the albino rat (author's transl)]

Anaesthesist. 1977 Oct;26(10):571-4.
[Article in German]

Abstract

In respect of controls the beta-cells of the Islets of Langerhans in fed rats showed a significant decrease in nuclear volume after 40 min of anaesthesia with Thiobutabarbitone Sodium in a double-maximum-load dose. The alpha-cells and the cells of the exocrine pancreas do not show such alteration. The reduction in beta-cell acitivity is referred to a time and dose dependent effect of narcosis on the metabolism of the beta-cells and possible membrane phenomena. According to the morphological picture the otherwise missing signs of impaired function of the cells indicate a peripheral disturbance of glucose utilization during nacrosis. The blood-sugar levels support the proposed explanation.

Publication types

  • English Abstract

MeSH terms

  • Anesthesia
  • Animals
  • Blood Glucose / analysis
  • Cell Nucleus
  • Islets of Langerhans / drug effects*
  • Karyometry
  • Male
  • Membranes
  • Pancreas / drug effects*
  • Rats
  • Thiobarbiturates / pharmacology*
  • Time Factors

Substances

  • Blood Glucose
  • Thiobarbiturates