Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative

Caishui Yang; Xin Li; Junying Zhang; Yaojing Chen; He Li; Dongfeng Wei; Peng Lu; Ying Liang; Zhen Liu; Ni Shu; Fang Wang; Qing Guan; Wuhai Tao; Qingshan Wang; Jianjun Jia; Lin Ai; Ruixue Cui; Yanping Wang; Dantao Peng; Wei Zhang; Kewei Chen; Xiaomin Wang; Jizong Zhao; Yongyan Wang; Qi Dong; Jun Wang; Zhanjun Zhang; Beijing Aging Brain Rejuvenation Initiative workgroup

doi:10.1002/alz.12326

Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative

Alzheimers Dement. 2021 Oct;17(10):1610-1618. doi: 10.1002/alz.12326. Epub 2021 Mar 31.

Authors

Caishui Yang¹, Xin Li¹, Junying Zhang², Yaojing Chen¹, He Li², Dongfeng Wei², Peng Lu¹, Ying Liang³, Zhen Liu⁴, Ni Shu¹, Fang Wang⁵, Qing Guan⁶, Wuhai Tao⁶, Qingshan Wang⁷, Jianjun Jia⁸, Lin Ai⁹, Ruixue Cui¹⁰, Yanping Wang², Dantao Peng¹¹, Wei Zhang¹², Kewei Chen¹³, Xiaomin Wang¹⁴, Jizong Zhao¹⁵, Yongyan Wang^{1

2}, Qi Dong¹, Jun Wang¹, Zhanjun Zhang¹; Beijing Aging Brain Rejuvenation Initiative workgroup

Affiliations

¹ State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
² Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China.
³ School of Biomedical Engineering, Capital Medical University, Beijing, China.
⁴ National Institute on Drug Dependence, Peking University, Beijing, China.
⁵ Dongcheng District Community Health Service Centre, Beijing, China.
⁶ School of Psychology and Society, Shenzhen University, Shenzhen, China.
⁷ Beijing Northern Hospital, China North Industries Group, Beijing, China.
⁸ Department of Geriatric Neurology, Chinese PLA General Hospital, Beijing, China.
⁹ Department of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
¹⁰ Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹¹ Department of Neurology, China-Japan Friendship Hospital, Beijing, China.
¹² Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
¹³ Banner Alzheimer's Institute, Phoenix, Arizona, USA.
¹⁴ School of Basic Medicine, Capital Medical University, Beijing, China.
¹⁵ Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

PMID: 33792187
DOI: 10.1002/alz.12326

Abstract

Facing considerable challenges associated with aging and dementia, China urgently needs an evidence-based health-care system for prevention and management of dementia. The Beijing Aging Brain Rejuvenation Initiative (BABRI) is a community-based cohort study initiated in 2008 that focuses on asymptomatic stages of dementia, aims to develop community-based prevention strategies for cognitive impairment, and provides a platform for scientific research and clinical trials. Thus far, BABRI has recruited 10,255 participants (aged 50 and over, 60.3% female), 2021 of whom have been followed up at least once at a 2- or 3-year interval. This article presents aims and study design of BABRI; summarizes preliminary behavioral and neuroimaging findings on mild cognitive impairment (MCI) and results of clinical trials on MCI; and discusses issues concerning early prevention in community, MCI diagnosis methods, and applications of database of aging and dementia. BABRI is proposed to build a systematic framework on brain health in old age.

Keywords: Alzheimer's disease; Chinese elderly; brain aging; cognitive aging; cognitive impairment; cognitive training; cohort study; community-based; dementia; early prevention; longitudinal study.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aging / physiology*
Alzheimer Disease / diagnosis*
Beijing
China
Cognitive Dysfunction* / diagnostic imaging
Cognitive Dysfunction* / prevention & control
Cohort Studies
Cross-Sectional Studies
Disease Progression*
Female
Humans
Longitudinal Studies
Male
Middle Aged
Neuroimaging