Abstract
A 73-year-old woman with metastatic vaginal mucosal melanoma that had progressed on ipilimumab and nivolumab experienced clinical and radiographic complete response to dual checkpoint inhibitor immunotherapy given in combination with high-dose plus low-dose radiation. General characteristics and treatment options in this disease are highlighted.
Keywords:
Abscopal effect; Immunotherapy; Low dose radiation; Vaginal mucosal melanoma.
Copyright © 2021 Elsevier Inc. All rights reserved.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Antineoplastic Agents, Immunological / administration & dosage
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Antineoplastic Agents, Immunological / therapeutic use
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Combined Modality Therapy
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Drug Therapy, Combination
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Female
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Humans
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Ipilimumab / administration & dosage
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Ipilimumab / therapeutic use
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Melanoma / diagnostic imaging
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Melanoma / secondary
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Melanoma / therapy*
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Mucous Membrane / pathology
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Neoplasm Metastasis
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Nivolumab / administration & dosage
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Nivolumab / therapeutic use
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Radiotherapy
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Urethral Neoplasms / diagnostic imaging
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Urethral Neoplasms / secondary
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Urethral Neoplasms / therapy*
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Vaginal Neoplasms / diagnostic imaging
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Vaginal Neoplasms / pathology
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Vaginal Neoplasms / therapy*
Substances
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Antineoplastic Agents, Immunological
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Ipilimumab
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Nivolumab