ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques

Jiadi Lv; Pin Yu; Zhenfeng Wang; Wei Deng; Linlin Bao; Jiangning Liu; Fengli Li; Qiangqiang Zhu; Nannan Zhou; Qi Lv; Guanpeng Wang; Shunyi Wang; Yabo Zhou; Jiangping Song; Wei-Min Tong; Yuying Liu; Chuan Qin; Bo Huang

doi:10.1038/s41423-021-00672-1

ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques

Cell Mol Immunol. 2021 May;18(5):1308-1310. doi: 10.1038/s41423-021-00672-1. Epub 2021 Apr 1.

Authors

Jiadi Lv^#¹, Pin Yu^#², Zhenfeng Wang¹, Wei Deng², Linlin Bao², Jiangning Liu², Fengli Li², Qiangqiang Zhu¹, Nannan Zhou¹, Qi Lv², Guanpeng Wang², Shunyi Wang², Yabo Zhou¹, Jiangping Song³, Wei-Min Tong⁴, Yuying Liu^{5

6}, Chuan Qin⁷, Bo Huang^{8

9

10}

Affiliations

¹ Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China.
² NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, CAMS and Comparative Medicine Center, Peking Union Medical College, Beijing, China.
³ State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, CAMS and Peking Union Medical College, Beijing, China.
⁴ Department of Pathology, Institute of Basic Medical Sciences, CAMS and Peking Union Medical College, Beijing, China.
⁵ Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China. 13161773902@163.com.
⁶ Clinical Immunology Center, CAMS, Beijing, China. 13161773902@163.com.
⁷ NHC Key Laboratory of Human Disease Comparative Medicine, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Institute of Laboratory Animal Science, CAMS and Comparative Medicine Center, Peking Union Medical College, Beijing, China. qinchuan@pumc.edu.cn.
⁸ Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College, Beijing, China. tjhuangbo@hotmail.com.
⁹ Clinical Immunology Center, CAMS, Beijing, China. tjhuangbo@hotmail.com.
¹⁰ Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. tjhuangbo@hotmail.com.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Angiotensin-Converting Enzyme 2 / genetics
Angiotensin-Converting Enzyme 2 / metabolism*
Animals
Basic Helix-Loop-Helix Transcription Factors
Binding Sites
COVID-19 / enzymology*
COVID-19 / genetics
COVID-19 / virology
Cell Line
Disease Models, Animal
Host-Pathogen Interactions
Humans
Lung / enzymology*
Lung / virology
Macaca
Mice
Promoter Regions, Genetic
Receptors, Aryl Hydrocarbon / genetics
Receptors, Aryl Hydrocarbon / metabolism*
SARS-CoV-2 / pathogenicity*

Substances

AHR protein, human
Ahr protein, mouse
Basic Helix-Loop-Helix Transcription Factors
Receptors, Aryl Hydrocarbon
ACE2 protein, human
Ace2 protein, mouse
Angiotensin-Converting Enzyme 2

Grants and funding

81788101/National Natural Science Foundation of China (National Science Foundation of China)