Adalimumab in the Management of Isotretinoin-Induced Acne Fulminans: Report of a Case

Claudio Marasca; Gabriella Fabbrocini; Luisa Abategiovanni; Elisa Camela; Mariateresa Nocerino; Adriana Di Guida; Gaia De Fata Salvatores

doi:10.1159/000512032

Adalimumab in the Management of Isotretinoin-Induced Acne Fulminans: Report of a Case

Skin Appendage Disord. 2021 Feb;7(2):115-119. doi: 10.1159/000512032. Epub 2021 Jan 21.

Authors

Claudio Marasca¹, Gabriella Fabbrocini¹, Luisa Abategiovanni¹, Elisa Camela¹, Mariateresa Nocerino¹, Adriana Di Guida¹, Gaia De Fata Salvatores¹

Affiliation

¹ Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Abstract

Acne fulminans (AF) is a rare, acute, and severe form of acne vulgaris often associated with systemic symptoms. Its treatment is challenging and controversial. We report a case of isotretinoin-induced AF (IIAF) in a 12-year-old boy resistant to traditional therapies (oral steroids and isotretinoin). The patient was successfully treated with adalimumab that can be considered an effective off-label option in the treatment of resistant IIAF in children.

Keywords: Acne fulminans; Adalimumab; Isotretinoin; Treatment.

Publication types

Case Reports