Cancer survivorship and quality of life outcomes of adolescents and young adults with lymphoma: An integrative review

Eur J Oncol Nurs. 2021 Jun:52:101948. doi: 10.1016/j.ejon.2021.101948. Epub 2021 Mar 20.


Purpose: Lymphoma is a common hematologic malignancy of adolescents and young adults. Cancer survivorship and quality of life are two outcomes studied to measure the types and scope of problems cancer patients experience leading to diagnosis, treatment, and long-term survivorship. This integrative literature review aims to review published literature in the adolescent and young adult lymphoma population, emphasizing cancer survivorship and quality of life outcomes.

Methods: The integrative review framework by Whittemore and Knafl was used as the guideline for this study. A literature search of three relevant health science databases, including PubMed, the Cumulative Index to Nursing and Allied Health Literature, and Ovid Emcare, was completed.

Results: Twelve publications were included in the review, including ten quantitative and two qualitative studies. The studies consisted of sample populations from the United States, England, Germany, and the Netherlands; one study was an international, Children's Oncology Group study. The included studies detailed the cancer survivorship and quality of life outcomes of young adults with lymphoma by quantitative retrospective and longitudinal analysis; two studies used descriptive qualitative and grounded theory methods. The limited qualitative and longitudinal research in adolescents and young adults with lymphoma demonstrates a gap in the lived experience of this cancer population and the adherence to long-term survivorship recommendations.

Conclusion: Future research in adolescents and young adults with lymphoma should employ longitudinal and qualitative designs to examine the quality of life from diagnosis through extended survivorship, and the experiences at diagnosis, treatment, post-treatment, and long-term follow up.

Keywords: Adolescents; Cancer survivorship; Integrative review; Lymphoma; Quality of life; Young adults.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Cancer Survivors / psychology*
  • Evaluation Studies as Topic
  • Humans
  • Lymphoma / psychology*
  • Outcome Assessment, Health Care
  • Quality of Life*
  • Survivorship*
  • Young Adult