Cold Plasma Systems and their Application in Surface Treatments for Medicine

Molecules. 2021 Mar 28;26(7):1903. doi: 10.3390/molecules26071903.


In this paper, a review of cold plasma setups and the physical and chemical processes leading to the generation of active species is presented. The emphasis is given to the interaction of cold plasmas with materials used in medical applications, especially medical implants as well as live cells. An overview of the different kinds of plasmas and techniques used for generation of active species, which significantly alter the surface properties of biomaterials is presented. The elemental processes responsible for the observed changes in the physio-chemical properties of surfaces when exposed to plasma are described. Examples of ongoing research in the field are given to illustrate the state-of-the-art at the more conceptual level.

Keywords: RONS; atmospheric plasmas; plasma material interactions; plasma medicine; plasmas.

Publication types

  • Review

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry*
  • Biomedical Research / methods*
  • Cell Adhesion / drug effects
  • Cell Death / drug effects
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Electrons*
  • Humans
  • Plasma Gases / chemical synthesis
  • Plasma Gases / pharmacology*
  • Prostheses and Implants
  • Surface Properties
  • Wound Healing / drug effects*


  • Biocompatible Materials
  • Plasma Gases