LTβR Signaling Controls Lymphatic Migration of Immune Cells

Cells. 2021 Mar 29;10(4):747. doi: 10.3390/cells10040747.


The pleiotropic functions of lymphotoxin (LT)β receptor (LTβR) signaling are linked to the control of secondary lymphoid organ development and structural maintenance, inflammatory or autoimmune disorders, and carcinogenesis. Recently, LTβR signaling in endothelial cells has been revealed to regulate immune cell migration. Signaling through LTβR is comprised of both the canonical and non-canonical-nuclear factor κB (NF-κB) pathways, which induce chemokines, cytokines, and cell adhesion molecules. Here, we focus on the novel functions of LTβR signaling in lymphatic endothelial cells for migration of regulatory T cells (Tregs), and specific targeting of LTβR signaling for potential therapeutics in transplantation and cancer patient survival.

Keywords: Treg migration; lymphatic endothelial cells; lymphotoxin; lymphotoxin β receptor signaling; non-canonical nuclear factor κB pathway.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cell Movement*
  • Endothelial Cells / metabolism
  • Humans
  • Leukocytes / cytology*
  • Leukocytes / metabolism*
  • Lymphatic System / cytology*
  • Lymphotoxin beta Receptor / metabolism*
  • Signal Transduction*


  • Lymphotoxin beta Receptor