The Relationship between COVID-19 and Innate Immunity in Children: A Review

Children (Basel). 2021 Mar 30;8(4):266. doi: 10.3390/children8040266.


Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible for the pandemic viral pneumonia that was first identified in Wuhan, China, in December 2019, and has since rapidly spread around the world. The number of COVID-19 cases recorded in pediatric age is around 1% of the total. The immunological mechanisms that lead to a lower susceptibility or severity of pediatric patients are not entirely clear. At the same time, the immune dysregulation found in those children who developed the multisystem inflammatory syndrome (MIC-S) is not yet fully understood. The aim of this review is to analyze the possible influence of children's innate immune systems, considering the risk of contracting the virus, spreading it, and developing symptomatic disease or complications related to infection.

Keywords: COVID-19; MIC-S; SARS-CoV-2; children; coronavirus; innate immunity; pandemic.

Publication types

  • Review