Relationship between Vitamin Intake and Health-Related Quality of Life in a Japanese Population: A Cross-Sectional Analysis of the Shika Study

Nutrients. 2021 Mar 22;13(3):1023. doi: 10.3390/nu13031023.


Although epidemiological studies revealed a relationship between psychosocial states, such as depressive symptoms, and nutritional intake, limited information is currently available on vitamin intake. The Short Form-36 Health Survey (SF-36) is not limited to a specific disease, it is constructed based on a universal concept of health and is used to evaluate the Quality of life (QOL). A three-component scoring method was developed for "Physical component score (PCS)", "Mental component score (MCS)", and "Role/social score (RCS)". Collectively, these summary scores are called the "QOL summary score", which is regarded as a more detailed health summary score. In the present study, we aimed at epidemiologically examine the relationship between vitamin intake and QOL in middle-aged and elderly population in 3162 residents in Japan. In women, a multiple regression analysis showed a positive correlation between all vitamin intake and PCS scores, and between vitamin B6, folic acid, vitamin C, and MCS scores. In consideration of depression as MCS of SF-36 and chronic pain as PCS, an insufficient vitamin intake may affect QOL in women; however, a causal relationship has not yet been demonstrated.

Keywords: Short Form-36; health-related quality of life; vitamin.

MeSH terms

  • Cross-Sectional Studies
  • Female
  • Health Status*
  • Health Surveys / methods*
  • Health Surveys / statistics & numerical data*
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Nutritional Status
  • Quality of Life*
  • Surveys and Questionnaires
  • Vitamins / administration & dosage*


  • Vitamins