Th2 cell-derived histamine is involved in nasal Th2 infiltration in mice

Inflamm Res. 2021 May;70(5):539-541. doi: 10.1007/s00011-021-01458-x. Epub 2021 Apr 3.


Objective: Histamine derived from mast cells and basophils plays important roles in inducing allergic symptoms. Although T cells also produce histamine, the involvement of the histamine produced from T cells has remained enigmatic. We sought to reveal the roles of T helper 2 (Th2) cell-derived histamine in nasal allergic disorders.

Methods: The histamine production from Th2 cells was measured by EIA. The mRNA expression of histidine decarboxylase (HDC) was measured by real-time PCR. To investigate the roles of Th2 cell-derived histamine in vivo, we analyzed an antigen-specific Th2 cell transfer mouse model.

Results: Th2 cells produced histamine by T cell receptor stimulation, and these properties were specific for Th2 cells, but not Th1 cells and naïve CD4 T cells. The histamine produced from Th2 cells was involved in the infiltrations of Th2 cells in response to antigen exposure.

Conclusion: These results suggest that Th2 cell-derived histamine play important roles in nasal allergic disorders.

Keywords: Antigen; Histamine; Histidine decarboxylase; Th2 cell.

MeSH terms

  • Allergens / immunology
  • Animals
  • Cell Movement
  • Histamine / immunology*
  • Histidine Decarboxylase / genetics
  • Mice, Inbred BALB C
  • Mice, Knockout
  • Nasal Mucosa / immunology*
  • Ovalbumin / immunology
  • Rhinitis, Allergic / immunology*
  • Th2 Cells / immunology*
  • Th2 Cells / physiology
  • Th2 Cells / transplantation


  • Allergens
  • Histamine
  • Ovalbumin
  • Histidine Decarboxylase