Abstract
Cytochrome b deficiency in the peripheral granulocytes of two male patients with chronic granulomatous disease was demonstrated by an immunocytochemical assay using a monoclonal antibody, 7D5, against human neutrophil cytochrome b. A mosaic of cytochrome b positive and negative neutrophils, indicating a carrier state in an X-linked trait, was found in the mother of patient 1 but not in the mother of patient 2.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Monoclonal
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Child
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Cytochrome b Group / blood
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Cytochrome b Group / deficiency*
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Cytochrome b Group / immunology
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Female
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Genetic Linkage
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Granulomatous Disease, Chronic / blood*
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Granulomatous Disease, Chronic / genetics
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Humans
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Immunohistochemistry
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Male
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Neutrophils / metabolism*
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X Chromosome
Substances
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Antibodies, Monoclonal
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Cytochrome b Group