Placental and milk transfer of chloroquine in humans

Ther Drug Monit. 1988;10(2):147-9. doi: 10.1097/00007691-198802000-00004.


The placental and milk transfer of chloroquine was studied in seven subjects and six subjects, respectively. Seven pregnant women at term were administered chloroquine phosphate (5 mg/kg) i.m. The maternal blood and arterial and venous umbilical cord blood were obtained during delivery. The maternal chloroquine blood levels varied from 0.438 to 1.193 micrograms/ml. The venous cord blood ranged from 0.607 to 0.869, whereas the arterial levels ranged from 0.480 to 0.905 micrograms/ml. Six subjects who were administered chloroquine phosphate (5 mg/kg) postpartum had chloroquine milk levels of 0.192-0.319 micrograms/ml. The milk:blood ratio ranged from 0.268 to 0.462. Chloroquine readily crossed the placenta and was excreted into the breast milk.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Chloroquine / administration & dosage
  • Chloroquine / pharmacokinetics*
  • Female
  • Fetal Blood / metabolism
  • Humans
  • Injections, Intramuscular
  • Milk, Human / metabolism*
  • Placenta / metabolism*
  • Pregnancy


  • Chloroquine