CRISPR/Cas9 Mediated Deletion of the Angiotensinogen Gene Reduces Hypertension: A Potential for Cure?

Hypertension. 2021 Jun;77(6):1990-2000. doi: 10.1161/HYPERTENSIONAHA.120.16870. Epub 2021 Apr 5.

Abstract

[Figure: see text].

Keywords: angiotensinogen; follow-up studies; hepatocytes; liver; sodium.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiotensinogen / genetics*
  • Angiotensinogen / metabolism
  • Animals
  • CRISPR-Cas Systems
  • Cell Line
  • Gene Deletion*
  • Hypertension / genetics*
  • Hypertension / metabolism
  • Liver / metabolism*
  • Rats
  • Rats, Wistar

Substances

  • Angiotensinogen