Role and Mechanism of Gut Microbiota in Human Disease

Yinwei Chen; Jinghua Zhou; Li Wang

doi:10.3389/fcimb.2021.625913

Role and Mechanism of Gut Microbiota in Human Disease

Front Cell Infect Microbiol. 2021 Mar 17:11:625913. doi: 10.3389/fcimb.2021.625913. eCollection 2021.

Authors

Yinwei Chen¹, Jinghua Zhou^{2

3}, Li Wang^{2

4}

Affiliations

¹ School of Medicine, Hangzhou Normal University, Hangzhou, China.
² Institute of Aging Research, School of Medicine, Hangzhou Normal University, Hangzhou, China.
³ School of Medicine, Zhejiang University, Hangzhou, China.
⁴ Department of Evolutionary Studies of Biosystems, School of Advanced Sciences, Graduate University for Advanced Studies (SOKENDAI), Hayama, Japan.

Abstract

The human gut microbiome is a huge microbial community that plays an irreplaceable role in human life. With the further development of research, the influence of intestinal flora on human diseases has been gradually excavated. Gut microbiota (GM) dysbiosis has adverse health effects on the human body that will lead to a variety of chronic diseases. The underlying mechanisms of GM on human diseases are incredibly complicated. This review focuses on the regulation and mechanism of GM on neurodegenerative diseases, cardiovascular diseases, metabolic diseases and gastrointestinal diseases, thus providing a potential target for the prevention and treatment of disease.

Keywords: cardiovascular diseases; gastrointestinal diseases; gut microbiota; metabolic diseases; neurodegenerative diseases.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cardiovascular Diseases*
Dysbiosis
Gastrointestinal Microbiome*
Humans
Metabolic Diseases*
Microbiota*