Nucleus-Cytoskeleton Crosstalk During Mitotic Entry

Front Cell Dev Biol. 2021 Mar 18;9:649899. doi: 10.3389/fcell.2021.649899. eCollection 2021.


In preparation for mitosis, cells undergo extensive reorganization of the cytoskeleton and nucleus, so that chromosomes can be efficiently segregated into two daughter cells. Coordination of these cytoskeletal and nuclear events occurs through biochemical regulatory pathways, orchestrated by Cyclin-CDK activity. However, recent studies provide evidence that physical forces are also involved in the early steps of spindle assembly. Here, we will review how the crosstalk of physical forces and biochemical signals coordinates nuclear and cytoplasmic events during the G2-M transition, to ensure efficient spindle assembly and faithful chromosome segregation.

Keywords: centrosome; chromosome; cytoskeleton; mechanotransduction; mitosis; nuclear lamina; nucleus.

Publication types

  • Review