Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors

Kang Hu; Qing-Kang Zheng; Rui-Jie Ma; Chao Ma; Zhi-Gang Sun; Nan Zhang

doi:10.3389/fcell.2021.661731

Krüppel-Like Factor 6 Splice Variant 1: An Oncogenic Transcription Factor Involved in the Progression of Multiple Malignant Tumors

Front Cell Dev Biol. 2021 Mar 18:9:661731. doi: 10.3389/fcell.2021.661731. eCollection 2021.

Authors

Kang Hu¹, Qing-Kang Zheng¹, Rui-Jie Ma², Chao Ma¹, Zhi-Gang Sun³, Nan Zhang⁴

Affiliations

¹ School of Clinical Medicine, Weifang Medical University, Weifang, China.
² Cheeloo College of Medicine, Shandong University, Jinan, China.
³ Department of Thoracic Surgery, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
⁴ Department of Oncology, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Abstract

Krüppel-like factor 6 (KLF6) is one of the most studied members of the specificity protein/Krüppel-like factor (SP/KLF) transcription factor family. It has a typical zinc finger structure and plays a pivotal role in regulating the biological processes of cells. Recently, it has been considered to play a role in combatting cancer. Krüppel-like factor 6 splice variant 1 (KLF6-SV1), being one of the alternative KLF6 splicing isoforms, participates in tumor occurrence and development and has the potential to become a new target for molecular targeted therapy, although its action mechanism remains to be determined. The purpose of this article is to provide a comprehensive and systematic review of the important role of KLF6-SV1 in human malignant tumors to provide novel insights for oncotherapy.

Keywords: EMT; KLF6; KLF6-SV1; apoptosis; invasion; proliferation.

Publication types

Review