Genital condylomas in pregnancy: use of trichloroacetic acid and laser therapy

Am J Obstet Gynecol. 1988 Jun;158(6 Pt 1):1407-16. doi: 10.1016/0002-9378(88)90375-4.


Genital condylomas in pregnancy pose several management problems for the obstetrician, including the mechanical problems of large condylomas and the issues relating to transmission of the human papillomavirus to the fetus during delivery. Transmission of papillomavirus occurs infrequently, but respiratory papillomatosis can result in mortality or lifelong morbidity. We evaluate our experience in treating condylomas in 32 pregnant women, using carbon dioxide laser therapy and 85% trichloroacetic acid. Condylomas in 31 (97%) of 32 women were controlled with this combination therapy. The only maternal complication was an episode of acute pyelonephritis secondary to urethral catheterization. One patient had premature rupture of the membranes 4 days after laser therapy and subsequently was delivered of a healthy neonate at 36 4/7 weeks. Prenatal photovaporization of condylomas appears to offer a method of treatment with a low complication and recurrence rate and helps avert the dilemma of whether patients with extensive genital condylomas should be delivered by cesarean section.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Combined Modality Therapy
  • Condylomata Acuminata / drug therapy*
  • Condylomata Acuminata / mortality
  • Condylomata Acuminata / surgery*
  • Drug Evaluation
  • Female
  • Humans
  • Infant Mortality
  • Infant, Newborn
  • Laser Therapy*
  • Michigan
  • Postoperative Complications / epidemiology
  • Pregnancy
  • Pregnancy Complications, Neoplastic / drug therapy*
  • Pregnancy Complications, Neoplastic / mortality
  • Pregnancy Complications, Neoplastic / surgery*
  • Retrospective Studies
  • Trichloroacetic Acid / therapeutic use*
  • Vaginal Neoplasms / drug therapy*
  • Vaginal Neoplasms / mortality
  • Vaginal Neoplasms / surgery*
  • Vulvar Neoplasms / drug therapy*
  • Vulvar Neoplasms / mortality
  • Vulvar Neoplasms / surgery*


  • Trichloroacetic Acid