Bullous pemphigoid in patients receiving peritoneal dialysis: a case series and a literature survey

Ren Fail. 2021 Dec;43(1):651-657. doi: 10.1080/0886022X.2021.1910045.


Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease. Although several cases of BP in end-stage renal disease patients receiving peritoneal dialysis (PD) or hemodialysis have been reported, the incidence of BP in these patients remains unknown. We recently experienced three PD patients diagnosed with BP. The skin injury was likely to be a trigger of BP in all the three PD patients. Nifedipine and icodextrin exposures were possible factors directly or indirectly affecting the onset of BP, because they were common in the three cases. We also report that the incidence of BP in PD patients was 3/478.3 person-years in a single-center 10-year study. This case series with a literature survey describes that the skin and tissue injuries are potential triggers responsible for the onset of BP in dialysis patients and that the incidence of BP in these patients seems to be much higher than that in the general population.

Keywords: Bullous pemphigoid; hemodialysis; incidence; peritoneal dialysis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Autoantibodies / metabolism
  • Female
  • Humans
  • Icodextrin / adverse effects
  • Kidney Failure, Chronic / therapy*
  • Male
  • Middle Aged
  • Nifedipine / adverse effects
  • Pemphigoid, Bullous / etiology*
  • Pemphigoid, Bullous / immunology
  • Peritoneal Dialysis / adverse effects*
  • Skin / pathology*


  • Autoantibodies
  • Icodextrin
  • Nifedipine