[COPD, anxiety-depression and cognitive disorders: Does inflammation play a major role?]

Rev Mal Respir. 2021 Apr;38(4):357-371. doi: 10.1016/j.rmr.2021.03.004. Epub 2021 Apr 2.
[Article in French]


COPD is a chronic respiratory disease, often associated with extrapulmonary manifestations. Co-morbidities, including anxiety, depression and cognitive impairment, worsen its progression and quality of life. The prevalence of these disorders is high, yet they are often poorly understood and inadequately managed. In the development of psychological disorders, there is accumulated evidence highlighting the major role of systemic inflammation, as well as chronic disease, genetics, the consequences of smoking, hypoxaemia, oxidative stress, and the gut microbiome In addition to traditional treatments such as bronchodilatator medications, respiratory rehabilitation and smoking cessation, systemic inflammation is an interesting therapeutic target, with the use of anti-inflammatory drugs, anti-cytokines, and nutritional interventions.

Keywords: BPCO; COPD; Cognitive disorders; Depression; Dépression; Inflammation systémique; Psychiatric disorders; Systemic inflammation; Troubles cognitifs; Troubles psychiatriques.

Publication types

  • Review

MeSH terms

  • Anxiety / epidemiology
  • Anxiety / etiology
  • Anxiety / therapy
  • Cognition
  • Depression* / epidemiology
  • Depression* / etiology
  • Depression* / therapy
  • Humans
  • Inflammation / complications
  • Inflammation / epidemiology
  • Inflammation / therapy
  • Pulmonary Disease, Chronic Obstructive* / complications
  • Pulmonary Disease, Chronic Obstructive* / diagnosis
  • Pulmonary Disease, Chronic Obstructive* / epidemiology
  • Quality of Life