Coproduction of Tet(X7) Conferring High-Level Tigecycline Resistance, Fosfomycin FosA4, and Colistin Mcr-1.1 in Escherichia coli Strains from Chickens in Egypt

Antimicrob Agents Chemother. 2021 May 18;65(6):e02084-20. doi: 10.1128/AAC.02084-20. Print 2021 May 18.

Abstract

The plasmid-mediated tet(X7) conferring high-level tigecycline resistance was identified in five mcr-1.1-positive Escherichia coli strains (ST10 [n = 3] and ST155 [n = 2]) isolated from chickens in Egypt. Two fosfomycin-resistant fosA4-carrying IncFII plasmids (∼79 kb in size) were detected. Transposase ISCR3 (IS91 family) is syntenic with tet(X7) in all isolates, suggesting its role in the mobilization of tet(X7). To our knowledge, this is the first global report of ST4-IncHI2 plasmids cocarrying tet(X7) and mcr-1.1 from chickens.

Keywords: Egypt; Escherichia coli; FosA4; Mcr-1.1; Tet(X7); chicken; colistin resistance; fosfomycin; tigecycline resistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Chickens
  • Colistin / pharmacology
  • Drug Resistance, Bacterial / genetics
  • Egypt
  • Escherichia coli / genetics
  • Escherichia coli Infections*
  • Escherichia coli Proteins* / genetics
  • Fosfomycin* / pharmacology
  • Plasmids / genetics
  • Tigecycline

Substances

  • Anti-Bacterial Agents
  • Escherichia coli Proteins
  • MCR-1 protein, E coli
  • Fosfomycin
  • Tigecycline
  • Colistin